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首页> 外文OA文献 >Effect of Prophylactic Fluconazole on the Frequency of Fungal Infections, Amphotericin B Use, and Health Care Costs in Patients Undergoing Intensive Chemotherapy for Hematologic Neoplasias
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Effect of Prophylactic Fluconazole on the Frequency of Fungal Infections, Amphotericin B Use, and Health Care Costs in Patients Undergoing Intensive Chemotherapy for Hematologic Neoplasias

机译：预防性氟康唑对正在进行血液学增生性化疗的患者进行真菌感染的频率，两性霉素B的使用以及医疗费用的影响

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Fungal infections are a major problem in patients with hematologic malignancy. Attempts to reduce their frequency with antifungal agents have not been successful. A double-blind, controlled, single-center trial was conducted with 96 consecutive patients undergoing 154episodes of chemotherapy. Patients received 400 mg of fluconazole or placebo until bone marrow recovery or initiation of intravenous amphotericin B infusions. End points were amphotericin B use, fungal infection, stable neutrophil count >0.5 × 109/L, toxicity precluding further fluconazole use, and death. By KaplanMeier estimation, the time to initiation of amphotericin B therapy was shorter in 76 patients treated with placebo than in 75 treated with fluconazole (P = .003). Also, fluconazole reduced the number of febrile days by 20% (P = .002) and prevented oropharyngeal candidiasis (1/75 vs. 9/76, P = .018). The frequency of deep mycoses (8/76 vs. 8/75) and outcome were unaffected. Fluconazole did not have a favorable effect on infection-related health care costs and was associated with prolonged severe neutropenia (P = .01)
机译：真菌感染是血液系统恶性肿瘤患者的主要问题。尝试降低使用抗真菌剂的频率尚未成功。对连续96例接受154疗程化疗的患者进行了双盲，对照，单中心试验。患者接受400 mg氟康唑或安慰剂，直至骨髓恢复或开始静脉注射两性霉素B。终点为使用两性霉素B，真菌感染，嗜中性粒细胞计数稳定> 0.5×109 / L，毒性（排除进一步使用氟康唑）和死亡。根据KaplanMeier的估计，安慰剂治疗的76名患者开始两性霉素B治疗的时间比氟康唑治疗的75名患者更短（P = 0.003）。同样，氟康唑将发热天数减少了20％（P = .002），并预防了口咽念珠菌病（1/75对9/76，P = .018）。深部霉菌病的发生频率（8/76比8/75）和预后没有受到影响。氟康唑对与感染有关的卫生保健费用没有有利影响，并且与长期严重中性粒细胞减少有关（P = 0.01）

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